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Publication

  • Why Label-Free Assays
  • Drug Discovery Solutions
    • Overview
    • Assay Development
    • High-Throughput Screening
    • SAMDI Affinity Selection Mass Spectrometry (ASMS) Technology
    • Small Molecule Compound Libraries
    • Cell-Based Assays
    • Substrate Specificity Profiling
    • Beyond Label-Free
      • Optical Assay Solutions
      • Radioactivity Assay Solutions
  • Scientific Resources
  • About Us
    • About Us
    • Executive Leadership
    • Board of Directors
    • Strategic Partnerships
    • Recognition and Awards
    • News
    • Events
    • Careers
  • Contact Us

Opportunities and Challenges in Targeting the Proofreading Activity of SARS-CoV-2 Polymerase Complex

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic. While the development of vaccines…

Label-Free Duplex SAMDI-MS Screen Reveals Novel SARS-CoV-2 3CLpro Inhibitors

Abstract The 3-chymotrypsin-like cysteine protease (3CLpro) of severe acute respiratory syndrome conoravirus 2 (SARS-CoV-2) remains a promising therapeutic target to…

How ASMS Offers More Than Seeing What Sticks

The ability to rapidly identify small molecules that non-covalently bind to a specific target is a critical tool that will…

High-Throughput Affinity Selection Mass Spectrometry (ASMS) Using SAMDI-MS to Identify Small-Molecule Binders of the Human Rhinovirus 3C Protease

Abstract Affinity selection mass spectrometry (ASMS) has emerged as a powerful high-throughput screening tool used in drug discovery to identify…

Development of a Novel Label-Free and High-Throughput Arginase-1 Assay Using Self-Assembled Monolayer Desorption Ionization Mass Spectrometry

Abstract Arginase-1, an enzyme that catalyzes the reaction of L-arginine to L-ornithine, is implicated in the tumor immune response and…

Label-Free Screening of SARS-CoV-2 NSP14 Exonuclease Activity Using SAMDI Mass Spectrometry

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for the global COVID-19 pandemic. Nonstructural protein 14…

Dual Inhibition of SARS-CoV-2 and Human Rhinovirus with Protease Inhibitors in Clinical Development

Abstract The 3-chymotrypsin-like cysteine protease (3CLpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is considered a major target for…

Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic that began in 2019. The…

Publication – A Mass Spectrometric Assay of METTL3/ METTL14 Methyltransferase Activity

Abstract A variety of covalent modifications of RNA have been identified and demonstrated to affect RNA processing, stability, and translation….

An Immobilized Enzyme Reactor for Spatiotemporal Control over Reaction Products

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SAMDI Tech, Inc.
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Suite 220S
Chicago, IL 60616

Phone: 312.235.3575

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  • Why Label-Free Assays
  • Drug Discovery Solutions
    • Overview
    • Assay Development
    • High-Throughput Screening
    • SAMDI Affinity Selection Mass Spectrometry (ASMS) Technology
    • Small Molecule Compound Libraries
    • Cell-Based Assays
    • Substrate Specificity Profiling
    • Beyond Label-Free
      • Optical Assay Solutions
      • Radioactivity Assay Solutions
  • Scientific Resources
  • About Us
    • About Us
    • Executive Leadership
    • Board of Directors
    • Strategic Partnerships
    • Recognition and Awards
    • News
    • Events
    • Careers
  • Contact Us
  • Careers
  • Search