High-Throughput Affinity Selection Mass Spectrometry (ASMS) Using SAMDI-MS to Identify Small-Molecule Binders of the Human Rhinovirus 3C Protease
Abstract Affinity selection mass spectrometry (ASMS) has emerged as a powerful high-throughput screening tool used in drug discovery to identify…
Development of a Novel Label-Free and High-Throughput Arginase-1 Assay Using Self-Assembled Monolayer Desorption Ionization Mass Spectrometry
Abstract Arginase-1, an enzyme that catalyzes the reaction of L-arginine to L-ornithine, is implicated in the tumor immune response and…
Label-Free Screening of SARS-CoV-2 NSP14 Exonuclease Activity Using SAMDI Mass Spectrometry
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for the global COVID-19 pandemic. Nonstructural protein 14…
Dual Inhibition of SARS-CoV-2 and Human Rhinovirus with Protease Inhibitors in Clinical Development
Abstract The 3-chymotrypsin-like cysteine protease (3CLpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is considered a major target for…
Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic that began in 2019. The…
Publication – A Mass Spectrometric Assay of METTL3/ METTL14 Methyltransferase Activity
Abstract A variety of covalent modifications of RNA have been identified and demonstrated to affect RNA processing, stability, and translation….
An Immobilized Enzyme Reactor for Spatiotemporal Control over Reaction Products
An Unusual Salt Effect in an Interfacial Nucleophilic Substitution Reaction
Traceless Immobilization of Analytes for High Throughput Experiments with SAMDI Mass Spectrometry
Abstract: Label-free assays, and particularly those based on the combination of mass spectroscopy with surface chemistries, enable high-throughput experiments of…