Label-Free HTS of SARS-CoV-2 NSP14 Exonuclease
SARS-CoV-2 NSP14 exonuclease (ExoN) activity is critical for viral replication fidelity and therefore represents an attractive antiviral target. Drug discovery…
Label-Free Deacetylase Assays Using SAMDI
Epigenetic modications of histones such as acetylation cause conformational changes in the chromatin structure, thereby regulating transcriptional activity. Histone acetyltransferases…
Cell-Based Assays for Cytotoxicity
The ability to assess the impact of small molecule drugs on cellular health is a powerful tool in drug discovery…
Radioactivity Assays for Methyltransferases
Methyltransferases have emerged as valuable therapeutic targets in cancer and other pathologies. This enzyme class includes protein and RNA methyltransferases…
SAMDI Affinity Selection Mass Spectrometry (ASMS)
SAMDI Affinity Selection Mass Spectrometry is a universal approach for the discovery of small molecules that bind specifically to target…
Label-Free Phosphatase Assays
Phosphatases are enzymes that catalyze the removal of phosphate groups from distinct substrates. They can be broadly characterized into classes…
Label-Free Kinase Assays
Kinases have long been implicated in several pathologies including cancer. Kinases are broadly classified based on their target substrate, such…
Label-Free Demethylase Assays
Lysine demethylases (KDMs) play a central role in epigenetic regulation. There are 27 KDMs separated into two classes that function…
Label-Free Methyltransferase Assays
Lysine Methyltransferases are enzymes that play a critical role in epigenetic control of gene expression by facilitating transfer of one,…
Label-Free Arginase Assays
Arginase catalyzes the hydrolysis of L-arginine to L-ornithine and urea. Ornithine serves as the biosynthetic precursor of proline, a critical…