Label-Free Deacetylase Assays Using SAMDI

Epigenetic modications of histones such as acetylation cause conformational changes in the chromatin structure, thereby regulating transcriptional activity. Histone acetyltransferases…

Label-Free Phosphatase Assays

Phosphatases are enzymes that catalyze the removal of phosphate groups from distinct substrates. They can be broadly characterized into classes…

Label-Free Kinase Assays

Kinases have long been implicated in several pathologies including cancer. Kinases are broadly classified based on their target substrate, such…

Label-Free Demethylase Assays

Lysine demethylases (KDMs) play a central role in epigenetic regulation. There are 27 KDMs separated into two classes that function…

Label-Free Methyltransferase Assays

Lysine Methyltransferases are enzymes that play a critical role in epigenetic control of gene expression by facilitating transfer of one,…