Kinases have long been implicated in several pathologies including cancer. Kinases are broadly classified based on their target substrate, such as protein kinases, lipid kinases, and small molecule kinases. Protein kinases, for example, transfer phosphate groups most often to either serine, threonine, or tyrosine residues. Emerging evidence has led to a renewed interest in kinases as therapeutic targets.
What We Offer
SAMDI Tech offers a plug-and-play format for quantitative analysis of kinase activity using native substrates. Analytes including peptides, oligonucleotides, lipids, and small molecules can be captured and purified onto SAMDI 384 or 1536 biochip arrays for analysis by mass spectrometry. The SAMDI assay distinguishes distinct kinase activities and enables detection of multiple phosphorylation events and multiplex assays.