The Fast and Victorious: Level Up Your Drug Discovery With Innovative Mass Spectrometry
Mass Spectrometry Gaining Momentum for Biochemical Assay Development and Screening
The goal of drug discovery is clear: reveal chemical matter that generates the most effective response towards a particular target…
Application of MALDI-MS for HTS and SAR
Disrupting Drug Discovery Research From Assay Development to Lead Compound
High-throughput screening remains one of the most powerful, unbiased approaches for small molecule drug discovery. Today, the toolbox for high-throughput…
Label-Free Phosphatase Assays
Phosphatases are enzymes that catalyze the removal of phosphate groups from distinct substrates. They can be broadly characterized into classes…
Label-Free Kinase Assays
Kinases have long been implicated in several pathologies including cancer. Kinases are broadly classified based on their target substrate, such…
Traceless Immobilization of Analytes for High Throughput Experiments with SAMDI Mass Spectrometry
Abstract: Label-free assays, and particularly those based on the combination of mass spectroscopy with surface chemistries, enable high-throughput experiments of…
Combining SAMDI Mass Spectrometry and Peptide Arrays to Profile Phosphatase Activities
Design of Glycosylation Sites by Rapid Synthesis and Analysis of Glycosyltransferases
Identification of small molecule noncovalent binders utilizing SAMDI technology
Abstract: In recent years, the ability to unambiguously identify complex mixtures of analytes with high accuracy and resolving power in…