Pairing the Right Small Molecule Library with Innovative High-Throughput Screening Creates More Therapeutic Opportunity
An important step in initiating a high-throughput screening project is selecting the small molecule library to be screened against the…
Radioactivity Assays for Methyltransferases
Methyltransferases have emerged as valuable therapeutic targets in cancer and other pathologies. This enzyme class includes protein and RNA methyltransferases…
Accelerating Drug Discovery from Protein to Cells with Ultra High-Throughput SAMDI Mass Spectrometry
An Enabling Label-Free Platform for RNA Drug Discovery Using SAMDI Mass Spectrometry
Disrupting Drug Discovery Research From Assay Development to Lead Compound
High-throughput screening remains one of the most powerful, unbiased approaches for small molecule drug discovery. Today, the toolbox for high-throughput…
A Mass Spectrometric Assay for METTL3/14 Methyltransferase Activity
Small Molecule Libraries: Over One Million More Reasons to Choose SAMDI Tech
High-throughput screening is a powerful approach to reveal lead compounds to initiate a drug discovery program. A critical aspect of…
An Immobilized Enzyme Reactor for Spatiotemporal Control over Reaction Products
An Unusual Salt Effect in an Interfacial Nucleophilic Substitution Reaction
Traceless Immobilization of Analytes for High Throughput Experiments with SAMDI Mass Spectrometry
Abstract: Label-free assays, and particularly those based on the combination of mass spectroscopy with surface chemistries, enable high-throughput experiments of…