New Technologies in Cell-Based Assays Create More Efficiencies by Increasing Throughput
Cell-based assays offer a powerful platform for quantifying modulation of cellular targets by small molecule synthetic compounds or biomolecules. These…
Integrating Machine Learning in Drug Discovery: A Balancing Act of Intelligent Decisions and Artificial Results
One of the major challenges in small molecule drug discovery is the significant attrition rate of compounds through drug development….
Maximizing Outsourcing Models Beyond Time and Cost
The goal of drug discovery is clear: Identify the most promising leads in the shortest amount of time. Many companies…
Label-Free HTS of SARS-CoV-2 NSP14 Exonuclease
SARS-CoV-2 NSP14 exonuclease (ExoN) activity is critical for viral replication fidelity and therefore represents an attractive antiviral target. Drug discovery…
Spotlight Presentation: SAMDI Tech’s Unique Drug Discovery Solutions Go Above and Beyond
SLAS 2022 Highlights Key Trends in Assay Development and Screening
In the last several years, the speed at which information and data has become available and instantly accessible is incredible….
How ASMS Offers More Than Seeing What Sticks
The ability to rapidly identify small molecules that non-covalently bind to a specific target is a critical tool that will…
Webinar: Integrating Affinity Selection Mass Spectrometry (ASMS) Into a Drug Discovery Workflow
Abstract High-throughput screening remains one of the most powerful, unbiased approaches in drug discovery for revealing novel small molecule modulators…
Development of a Novel Label-Free and High-Throughput Arginase-1 Assay Using Self-Assembled Monolayer Desorption Ionization Mass Spectrometry
Abstract Arginase-1, an enzyme that catalyzes the reaction of L-arginine to L-ornithine, is implicated in the tumor immune response and…
Going Above and Beyond in Drug Discovery: Orthogonal Assays Aid in Selecting Promising Drug Leads
Developing a biochemical assay is one of the first steps in launching a drug discovery program. While initial screens often…