Integrating affinity selection mass spectrometry in a drug discovery workflow
High-throughput screening remains one of the most powerful, unbiased approaches in drug discovery for revealing novel small molecule modulators of…
Four Tips for Selecting a Small Molecule Screening Library
High-throughput screening remains one of the most powerful, unbiased approaches in drug discovery for revealing small molecule modulators of biochemical…
Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic that began in 2019. The…
Pairing the Right Small Molecule Library with Innovative High-Throughput Screening Creates More Therapeutic Opportunity
An important step in initiating a high-throughput screening project is selecting the small molecule library to be screened against the…
Ultra High-Throughput Affinity Selection Mass Spectrometry Assays
Accelerating Drug Discovery from Protein to Cells with Ultra High-Throughput SAMDI Mass Spectrometry
SAMDI Affinity Selection Mass Spectrometry
SAMDI Affinity Selection Mass Spectrometry is a universal approach for the discovery of small molecules that bind specifically to target…
Mass Spectrometry Gaining Momentum for Biochemical Assay Development and Screening
The goal of drug discovery is clear: reveal chemical matter that generates the most effective response towards a particular target…
Application of MALDI-MS for HTS and SAR
Disrupting Drug Discovery Research From Assay Development to Lead Compound
High-throughput screening remains one of the most powerful, unbiased approaches for small molecule drug discovery. Today, the toolbox for high-throughput…