Disrupting Drug Discovery Research From Assay Development to Lead Compound
High-throughput screening remains one of the most powerful, unbiased approaches for small molecule drug discovery. Today, the toolbox for high-throughput…
Hit-to-lead support: Enhancing lead optimization with label-free IC50 analysis and REDOX assays
High-throughput screening is one of the most powerful and unbiased approaches for identifying new drug leads. Up to millions of…
Small Molecule Libraries: Over One Million More Reasons to Choose SAMDI Tech
High-throughput screening is a powerful approach to reveal lead compounds to initiate a drug discovery program. A critical aspect of…
Label-Free Solutions: Receive Better Results Faster
Discovering a novel therapeutic candidate is a lengthy endeavor. Early steps may include developing a biochemical assay and performing a…
SAMDI Mass Spectrometry: Assaying Challenging Biochemical Targets
High-throughput biochemical assays offer a means to assess specific enzyme activities and identify compounds that directly modulate that activity. Most…
Multiplex High-Throughput Screening: Gain More Data in a Fraction of the Time
High-throughput screening enables rapid testing of up to millions of compounds to identify small molecule modulators of distinct biochemical activities….
An Immobilized Enzyme Reactor for Spatiotemporal Control over Reaction Products
An Unusual Salt Effect in an Interfacial Nucleophilic Substitution Reaction
Traceless Immobilization of Analytes for High Throughput Experiments with SAMDI Mass Spectrometry
Abstract: Label-free assays, and particularly those based on the combination of mass spectroscopy with surface chemistries, enable high-throughput experiments of…