Hit-to-lead support: Enhancing lead optimization with label-free IC50 analysis and REDOX assays
High-throughput screening is one of the most powerful and unbiased approaches for identifying new drug leads. Up to millions of…
Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase
A structure-activity relationship of non-peptide macrocyclic histone deacetylase inhibitors and their anti-proliferative and anti-inflammatory activities
Discovery of SIRT3 Inhibitors Using SAMDI Mass Spectrometry
Synthesis and Structure-Activity Relationship of 3-Hydroxypyridine-2-thione-Based Histone Deactylase Inhibitors
HTS of Small Molecule Libraries using SAMDI
High-throughput screening is a common strategy used to identify compounds that modulate biochemical activities, but many approaches depend on cumbersome…