Hit-to-lead support: Enhancing lead optimization with label-free IC50 analysis and REDOX assays
High-throughput screening is one of the most powerful and unbiased approaches for identifying new drug leads. Up to millions of…
Small Molecule Libraries: Over One Million More Reasons to Choose SAMDI Tech
High-throughput screening is a powerful approach to reveal lead compounds to initiate a drug discovery program. A critical aspect of…
Label-Free Phosphatase Assays
Phosphatases are enzymes that catalyze the removal of phosphate groups from distinct substrates. They can be broadly characterized into classes…
Label-Free Kinase Assays
Kinases have long been implicated in several pathologies including cancer. Kinases are broadly classified based on their target substrate, such…
Traceless Immobilization of Analytes for High Throughput Experiments with SAMDI Mass Spectrometry
Abstract: Label-free assays, and particularly those based on the combination of mass spectroscopy with surface chemistries, enable high-throughput experiments of…
Combining SAMDI Mass Spectrometry and Peptide Arrays to Profile Phosphatase Activities
Design of Glycosylation Sites by Rapid Synthesis and Analysis of Glycosyltransferases
Identification of small molecule noncovalent binders utilizing SAMDI technology
Abstract: In recent years, the ability to unambiguously identify complex mixtures of analytes with high accuracy and resolving power in…