Label-Free Deacetylase Assays Using SAMDI
Epigenetic modications of histones such as acetylation cause conformational changes in the chromatin structure, thereby regulating transcriptional activity. Histone acetyltransferases…
Webinar – Integrating Affinity Selection Mass Spectrometry (ASMS) Into a Drug Discovery Workflow
Abstract High-throughput screening remains one of the most powerful, unbiased approaches in drug discovery for revealing novel small molecule modulators…
Development of a Novel Label-Free and High-Throughput Arginase-1 Assay Using Self-Assembled Monolayer Desorption Ionization Mass Spectrometry
Abstract Arginase-1, an enzyme that catalyzes the reaction of L-arginine to L-ornithine, is implicated in the tumor immune response and…
Label-Free Screening of SARS-CoV-2 NSP14 Exonuclease Activity Using SAMDI Mass Spectrometry
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for the global COVID-19 pandemic. Nonstructural protein 14…
Blog – Integrating Affinity Selection Mass Spectrometry (ASMS) in a Drug Discovery Workflow
High-throughput screening remains one of the most powerful, unbiased approaches in drug discovery for revealing novel small molecule modulators of…
Pairing the Right Small Molecule Library with Innovative High-Throughput Screening Creates More Therapeutic Opportunity
An important step in initiating a high-throughput screening project is selecting the small molecule library to be screened against the…
Publication – A Mass Spectrometric Assay of METTL3/ METTL14 Methyltransferase Activity
Abstract A variety of covalent modifications of RNA have been identified and demonstrated to affect RNA processing, stability, and translation….