A Mass Spectrometric Assay of METTL3/ METTL14 Methyltransferase Activity
Abstract A variety of covalent modifications of RNA have been identified and demonstrated to affect RNA processing, stability, and translation….
Accelerating Drug Discovery from Protein to Cells with Ultra High-Throughput SAMDI Mass Spectrometry
An Enabling Label-Free Platform for RNA Drug Discovery Using SAMDI Mass Spectrometry
Mass Spectrometry Gaining Momentum for Biochemical Assay Development and Screening
The goal of drug discovery is clear: reveal chemical matter that generates the most effective response towards a particular target…
Disrupting Drug Discovery Research From Assay Development to Lead Compound
High-throughput screening remains one of the most powerful, unbiased approaches for small molecule drug discovery. Today, the toolbox for high-throughput…
Hit-to-lead support: Enhancing lead optimization with label-free IC50 analysis and REDOX assays
High-throughput screening is one of the most powerful and unbiased approaches for identifying new drug leads. Up to millions of…
Small Molecule Libraries: Over One Million More Reasons to Choose SAMDI Tech
High-throughput screening is a powerful approach to reveal lead compounds to initiate a drug discovery program. A critical aspect of…
Label-Free Phosphatase Assays
Phosphatases are enzymes that catalyze the removal of phosphate groups from distinct substrates. They can be broadly characterized into classes…
Label-Free Kinase Assays
Kinases have long been implicated in several pathologies including cancer. Kinases are broadly classified based on their target substrate, such…
Traceless Immobilization of Analytes for High Throughput Experiments with SAMDI Mass Spectrometry
Abstract: Label-free assays, and particularly those based on the combination of mass spectroscopy with surface chemistries, enable high-throughput experiments of…