Pairing the Right Small Molecule Library with Innovative High-Throughput Screening Creates More Therapeutic Opportunity
An important step in initiating a high-throughput screening project is selecting the small molecule library to be screened against the…
Publication – A Mass Spectrometric Assay of METTL3/ METTL14 Methyltransferase Activity
Abstract A variety of covalent modifications of RNA have been identified and demonstrated to affect RNA processing, stability, and translation….
Accelerating Drug Discovery from Protein to Cells with Ultra High-Throughput SAMDI Mass Spectrometry
Presentation: An Enabling Label-Free Platform for RNA Drug Discovery Using SAMDI Mass Spectrometry
Poster – An Enabling Label-Free Platform for RNA Drug Discovery Using SAMDI Mass Spectrometry
Mass Spectrometry Gaining Momentum for Biochemical Assay Development and Screening
The goal of drug discovery is clear: reveal chemical matter that generates the most effective response towards a particular target…
Disrupting Drug Discovery Research From Assay Development to Lead Compound
High-throughput screening remains one of the most powerful, unbiased approaches for small molecule drug discovery. Today, the toolbox for high-throughput…
Hit-to-lead support: Enhancing lead optimization with label-free IC50 analysis and REDOX assays
High-throughput screening is one of the most powerful and unbiased approaches for identifying new drug leads. Up to millions of…
Small Molecule Libraries: Over One Million More Reasons to Choose SAMDI Tech
High-throughput screening is a powerful approach to reveal lead compounds to initiate a drug discovery program. A critical aspect of…
Label-Free Phosphatase Assays
Phosphatases are enzymes that catalyze the removal of phosphate groups from distinct substrates. They can be broadly characterized into classes…