Label-Free Screening of SARS-CoV-2 NSP14 Exonuclease Activity Using SAMDI Mass Spectrometry
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for the global COVID-19 pandemic. Nonstructural protein 14…
Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic that began in 2019. The…
Ultra High-Throughput Affinity Selection Mass Spectrometry Assays
A Mass Spectrometric Assay of METTL3/ METTL14 Methyltransferase Activity
Abstract A variety of covalent modifications of RNA have been identified and demonstrated to affect RNA processing, stability, and translation….
Accelerating Drug Discovery from Protein to Cells with Ultra High-Throughput SAMDI Mass Spectrometry
The Fast and Victorious: Level Up Your Drug Discovery With Innovative Mass Spectrometry
An Enabling Label-Free Platform for RNA Drug Discovery Using SAMDI Mass Spectrometry
Mass Spectrometry Gaining Momentum for Biochemical Assay Development and Screening
The goal of drug discovery is clear: reveal chemical matter that generates the most effective response towards a particular target…
Application of MALDI-MS for HTS and SAR
Disrupting Drug Discovery Research From Assay Development to Lead Compound
High-throughput screening remains one of the most powerful, unbiased approaches for small molecule drug discovery. Today, the toolbox for high-throughput…