Opportunities and Challenges in Targeting the Proofreading Activity of SARS-CoV-2 Polymerase Complex
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic. While the development of vaccines…
Label-Free HTS of SARS-CoV-2 NSP14 Exonuclease
SARS-CoV-2 NSP14 exonuclease (ExoN) activity is critical for viral replication fidelity and therefore represents an attractive antiviral target. Drug discovery…
Spotlight Presentation: SAMDI Tech’s Unique Drug Discovery Solutions Go Above and Beyond
SLAS 2022 Highlights Key Trends in Assay Development and Screening
In the last several years, the speed at which information and data has become available and instantly accessible is incredible….
Webinar: Integrating Affinity Selection Mass Spectrometry (ASMS) Into a Drug Discovery Workflow
Abstract High-throughput screening remains one of the most powerful, unbiased approaches in drug discovery for revealing novel small molecule modulators…
Development of a Novel Label-Free and High-Throughput Arginase-1 Assay Using Self-Assembled Monolayer Desorption Ionization Mass Spectrometry
Abstract Arginase-1, an enzyme that catalyzes the reaction of L-arginine to L-ornithine, is implicated in the tumor immune response and…
Label-Free Screening of SARS-CoV-2 NSP14 Exonuclease Activity Using SAMDI Mass Spectrometry
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for the global COVID-19 pandemic. Nonstructural protein 14…
Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic that began in 2019. The…
Ultra High-Throughput Affinity Selection Mass Spectrometry (ASMS) Assays
Publication – A Mass Spectrometric Assay of METTL3/ METTL14 Methyltransferase Activity
Abstract A variety of covalent modifications of RNA have been identified and demonstrated to affect RNA processing, stability, and translation….